President Bashir Tests New Obama Policy on Sudan

/PRNewswire/ -- With the news that President Omar al-Bashir plans to travel to Turkey and Egypt in the coming days, President Obama faces the first test of his recently announced Sudan policy.

The Enough Project at the Center for American Progress, the Save Darfur Coalition, and the Genocide Intervention Network jointly released the following statement in reaction:

If President Obama and Secretary Clinton are unwilling to engage in personal diplomacy at the highest level to ensure that a wanted war criminal does not continue to travel with impunity to the capitals of key U.S. allies, it will send a powerful message that the administration isn't serious about implementing the Sudan strategy it just announced.

John Norris, Executive Director of the Enough Project, noted, "For Turkey, a member of NATO and an aspiring member of the European Union, to welcome President Bashir is frankly baffling. If Turkey is truly committed to the values that would make membership of the European Union possible, it should quickly make clear that President Bashir is absolutely unwelcome."

Jerry Fowler, President of the Save Darfur Coalition, added, "President Bashir's travel is a test of the administration's resolve on Sudan. If the President and Secretary of State let it happen without objection, Khartoum will get the message that the newly stated commitment to multilateral leadership is hollow. And for Turkey, it's an opportunity to align itself with the E.U., most Latin American countries, and the emerging practice in sub-Saharan Africa: Convey to Bashir that he shouldn't come unless he wants to risk arrest upon landing."

Sam Bell, Executive Director of Genocide Intervention Network, added, "Given the depth and breadth of U.S. engagement with Egypt, it is striking that the situation in Sudan - and Bashir's status as a war criminal - don't appear t be part of the recent conversation among senior officials. How can the administration expect to effectively implement its new plan if it doesn't make Sudan a top priority?"

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FDA Assessing Feasibility of Using Nanotechnology Test to Detect Anthrax Following a Bioterrorist Attack

The U.S. Food and Drug Administration has completed a "proof-of-concept" study of a test that quickly and accurately detects the presence of even the smallest amount of the deadly anthrax toxin.

"The FDA findings could form the basis of a test that allows earlier diagnosis of anthrax infection than currently possible," said Indira Hewlett, Ph.D., the senior author of the study and chief of the Laboratory of Molecular Virology, Office of Blood Research and Review, at the FDA's Center for Biologics Evaluation and Research (CBER). "The earlier those infected with anthrax can be treated, the better."

A proof-of-concept study is an initial investigation that aims to determine if a new scientific idea or concept holds promise for further development. A report on the results of this study appears in the March issue of Clinical and Vaccine Immunology.

Anthrax is an infectious disease caused by the bacterium Bacillus anthracis, a bacteria that forms spores, or dormant cells, which can come to life under the right temperature, nutrients and other conditions to allow growth. Anthrax occurs in humans after exposure to an infected animal or infected animal tissue or when anthrax spores are used as a bioterrorist weapon.

The proof-of-concept study developed by FDA researchers relies on a nanotechnology-based test platform built from tiny molecular-sized particles. This assay, the europium nanoparticle-based immunoassay (ENIA), was able to detect the presence of a protein made by the anthrax bacteria known as protective antigen (PA). PA combines with another protein called lethal factor to form anthrax lethal factor toxin, the protein that enters cells and causes toxic effects.

The researchers showed that ENIA is capable of detecting PA in quantities that are 100 times lower than current tests, such as the enzyme-linked immunosorbent assay (ELISA). Both the ELISA and ENIA rely on antibodies that have an affinity for the anthrax protein of interest.

The FDA test is a modified version of ELISA, which is already commonly used to detect anthrax and other infections. The researchers call their new test 'europium nanoparticle-based immunoassay,' because atoms of europium are key to the assay's sensitivity.

The ENIA uses molecular spheres (called nanospheres) covered with thousands of light-emitting atoms of europium that emit light, which acts as a signal that PA is present. The CBER team further enhanced the signal by modifying the nanospheres so they held additional atoms of europium, making the test more sensitive.

The ENIA detected PA in 100 percent of samples of mouse plasma compared to 36.4 percent through ELISA.

Nanotechnology-based tests like the ENIA are rapidly emerging as convenient tools for a variety of laboratory uses, according to Shixing Tang, M.D., Ph.D., a visiting associate scientist in the Laboratory of Molecular Virology, CBER. "ENIA has potential use in an emergency because its relatively simple design makes the technology adaptable to point-of-care uses," said Dr. Tang, the first author of the study.

The researchers developed the ENIA for PA in response to the increased interest in the scientific community for new anthrax assays following the 2001 U.S. anthrax attack that killed five people.

Co-authors of the article, "Detection of Anthrax Toxin by an Ultrasensitive Immunoassay Using Europium Nanoparticles," include Jiangqin Zhao (CBER), Mahtab Moayeri, Zhaochun Chen, Haijing Hu, Robert H. Purcell, and Stephen H. Leppla (National Institute of Allergy and Infectious Diseases, National Institutes of Health), and Harri Harma (University of Turku, Finland).

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